Penile SCC Grading
Feature-based G1–G3 grading, with any anaplastic feature sufficient for Grade 3 regardless of lower-grade findings.
Free with an accountLog in to calculate. You can explore the inputs and reference material below; results need a free student account.
Histologic grade has been consistently reported as an influential predictor of groin metastasis and dissemination in penile cancer. This tool is an educational and documentation-support aid only and does not replace professional pathologist judgment, institutional protocols, or the current edition of the applicable classification.
Reference
Grading criteria
| Grade | Criteria |
|---|---|
| G1 | Extremely well-differentiated carcinoma, with a minimal deviation from the morphology of normal/hyperplastic squamous epithelium. |
| G2 | More disorganized growth compared to Grade 1, higher nuclear-to-cytoplasmic ratio, evident mitoses, and — although present — less prominent keratinization. |
| G3 | Any proportion of anaplastic cells, identified as solid sheets or irregular small aggregates, cords, or nests of cells with little or no keratinization, high nuclear-to-cytoplasmic ratio, thick nuclear membranes, nuclear pleomorphism, clumped chromatin, prominent nucleoli, and numerous mitoses. |
Grade 3 is an override, not a majority vote
The source specifies "any proportion" of anaplastic cells — so a single qualifying Grade 3 focus is sufficient for a Grade 3 result, even in a tumor that is otherwise low-grade.
Grade 2 features are only decisive if no Grade 3 feature is present. Grade 1 is the default when neither higher-grade feature set applies.
Prognostic significance
Histologic grade has been consistently reported as an influential predictor of groin metastasis and dissemination of penile cancer.
Sources
The source excerpt used to build this tool cited three references (numbered 1–3) supporting the prognostic significance of histologic grade in penile cancer. Their full bibliographic entries were not included in the supplied text, so they are not reproduced here — consult the complete published protocol for exact references.